What should be done if a DRTB patient shows no clinical improvement?

If a patient diagnosed with drug-resistant tuberculosis (DRTB) shows no clinical improvement, it is crucial to reassess the treatment regimen to ensure it is still appropriate and effective. Requesting a repeat drug susceptibility test (DST) is the most logical action in this situation. This test helps determine if the patient's strain of tuberculosis has developed further resistance to the current medications being administered.

The results of the repeat DST can provide vital information that may guide clinicians in revising the treatment plan. For instance, if the test reveals additional resistance, the healthcare provider can adjust the medication regimen to include drugs to which the bacteria are still susceptible, thereby enhancing the chances of treatment success.

Continuing the current treatment without any adjustments, switching to another drug without proper testing, or discontinuing treatment can lead to treatment failure, further resistance, and the potential for worsening the patient's condition. Therefore, repeating the DST is essential for achieving the best possible outcome for a DRTB patient who is not improving clinically.