What should be monitored closely in patients taking 3HR regimen?

In patients undergoing the 3HR regimen, which consists of Rifampicin and Isoniazid given for three months, monitoring liver enzymes is crucial. This is because both Rifampicin and Isoniazid can have hepatotoxic effects, potentially leading to liver injury or dysfunction. Elevated liver enzymes can be indicative of drug-induced liver damage, which necessitates prompt evaluation and management.

Regular monitoring of liver function tests helps in early detection of any adverse effects related to these medications, allowing for timely interventions if necessary. Additionally, monitoring can ensure that the treatment remains safe and effective while minimizing the risks associated with hepatitis and other liver conditions that may arise from the regimen. By keeping a close watch on liver enzyme levels, healthcare providers can assess the patient's tolerance to the therapy and adjust the treatment plan as needed.