When taking oral contraceptive pills alongside anti-TB medications, it is emphasized to take them:

The correct answer emphasizes the importance of administering oral contraceptive pills and anti-TB medications at different times to avoid potential interactions that could affect the effectiveness of either treatment. Anti-TB medications can alter the metabolism of oral contraceptives, decreasing their effectiveness and increasing the risk of unplanned pregnancies.

Taking these medications long hours apart helps to minimize any absorption issues or metabolic interactions that may occur. This approach ensures that each medication can work as intended without interfering with the other, promoting both effective tuberculosis treatment and reliable contraceptive protection.

Other options suggest taking the medications too close together, which might lead to reduced efficacy of the contraceptives due to potential drug interactions. Therefore, spacing out the administration is crucial for maintaining the effectiveness of both therapies.