Which drug is associated with the presentation of orange-colored urine in a patient on first line drug treatment?

Rifampicin is well known for causing orange-red discoloration of bodily fluids, including urine, tears, and sweat. This effect is a result of rifampicin's chemical properties, which lead to its excretion in an altered form that stains these fluids. While isoniazid, pyrazinamide, and ethambutol have their own side effects, they do not typically cause any coloration changes in urine similar to those caused by rifampicin. For healthcare providers and patients, recognizing this side effect of rifampicin is important for distinguishing normal reactions from concerning symptoms that may arise during treatment. Additionally, understanding this side effect helps alleviate patient concerns when they notice an unexpected change in urine color.