Which drug should be avoided in DRTB patients with uncontrolled depression?

In the management of Drug-Resistant Tuberculosis (DRTB), careful consideration of the mental health status of patients is imperative, particularly for those with uncontrolled depression. Cycloserine is known to have potential neuropsychiatric side effects, which can exacerbate existing mental health issues. This drug can lead to symptoms such as mood swings, anxiety, and confusion, thereby posing a significant risk to patients already struggling with depression.

Given its propensity to worsen psychological conditions, cycloserine should be avoided in DRTB patients with uncontrolled depression. The other drugs listed do not carry the same level of concern regarding mental health exacerbations, making them potentially safer options for use in such patients. Therefore, the choice to avoid cycloserine in this specific patient population aligns with a holistic approach to treatment, emphasizing both physical and mental well-being.