Which statement about the use of Prothionamide is true?

The statement regarding starting Prothionamide (Pto) in two divided dosages for the first two weeks if the dosage is more than 250mg is accurate. This approach is important because it helps in managing potential side effects and optimizing patient adherence. Dividing the dose for the initial period allows the body to adjust to the medication, which can mitigate risks of toxicity, particularly gastrointestinal side effects, which are common with this drug.

Administering a high initial dose all at once could overwhelm the patient’s system, increasing the likelihood of adverse reactions and non-compliance. Therefore, this strategy of using a divided dosage in the early stages aligns with best practices for maximizing tolerance and ensuring better overall treatment outcomes for patients.

In contrast, while it is indeed important for certain medications to be taken on an empty stomach to enhance absorption, this is not universally applicable to Prothionamide and does not apply to the statement in question. Additionally, starting with a full dose without any gradual increase can be risky due to the reasons mentioned earlier, and any changes to dosing should be guided by specific clinical protocols rather than arbitrary shifts after one week.